Home  >  Products  >  HSC70 Interacting Protein (HIP, AAG2, Aging Associated Protein 2, FAM10A1, FLJ27260, HSPABP1, MGC129952, OTTHUMP00000028873, PRO0786, Progesterone Receptor Associated p48 Protein, Putative Tumor Suppressor ST13, Renal Carcinoma Antigen NY REN 33, SNC6, Su

HSC70 Interacting Protein (HIP, AAG2, Aging Associated Protein 2, FAM10A1, FLJ27260, HSPABP1, MGC129952, OTTHUMP00000028873, PRO0786, Progesterone Receptor Associated p48 Protein, Putative Tumor Suppressor ST13, Renal Carcinoma Antigen NY REN 33, SNC6, Su

Cat no: H7651-07A


Supplier: United States Biological
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ST13/HIP is a cytoplasmic co-chaperone involved in the regulation of Hsc70 chaperone activity and the maturation of progesterone receptor. ST13/HIP is made of two structural and functional domains, an NH2-terminal domain, responsible for the dimerization and the overall asymmetry of the molecule, and a COOH-terminal globular domain, both involved in Hsc70 and unfolded protein binding (1). By collaborating with other positive co-factors such as Hsp40 and the Hsp70-Hsp90 organizing protein (Hop), or competing with negative co-factors such as Bcl2-associated athanogen 1 (Bag1), ST13/HIP facilitates may facilitate the chaperone function of Hsc/Hsp70 in protein folding and repair, and in controlling the activity of regulatory proteins such as steroid receptors and regulators of proliferation or apoptosis (2). Applications: Suitable for use in Flow Cytometry, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Flow Cytometry: 1:150 Western Blot: 1:10,000-1:50,000 Immunohistochemistry: 1:100-1:250 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Manufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Catalogue number: H7651-07A
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: Flow Cytometry, Immunohistochemistry, Western Blot
Size: 100ul
Form: Supplied as a liquid in 50mM Tris-glycine, pH 7.4, 0.15M sodium chloride, 40% glycerol, 0.01% sodium azide, 0.05% BSA.
P type: Mab
Isotype: IgG
Purity: Supernatant
References: 1. Velten M, et al. J Biol Chem. 277(1):259-66, 2002 2. Shi ZZ, et al. J Zhejiang Univ Sci B. 8(3):170-6, 2007
Additional info: Recognizes human ST13/HIP. Species Crossreactivity: Mouse.

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