Home  >  Products  >  Granzyme B (C11, Cathespin G Like 1, CCPI,CGL 1, CGL1, CSP B, CSPB, CTLA 1, CTLA1, CTSGL 1,CTSGL1, Cytotoxic serine protease B, Cytotoxic T Lymphocyte Cytotoxic T lymphocyte proteinase 2, EC 3.4.21.79, Fragmentin 2, Granzyme 2, GRB, GZMB, HLP, Human lymph

Granzyme B (C11, Cathespin G Like 1, CCPI,CGL 1, CGL1, CSP B, CSPB, CTLA 1, CTLA1, CTSGL 1,CTSGL1, Cytotoxic serine protease B, Cytotoxic T Lymphocyte Cytotoxic T lymphocyte proteinase 2, EC 3.4.21.79, Fragmentin 2, Granzyme 2, GRB, GZMB, HLP, Human lymph

Cat no: G8957-15G


Supplier: United States Biological
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Granzymes are neutral serine proteases, which are stored in specialized lytic granules of cytotoxic T lymphocytes (CTLs) and in natural killer (NK) cells. A number of granzymes A to G, have been isolated and cloned from mouse CTLs and NK cells, however in man, fewer have been cloned and identified. One of these, human granzyme B, is involved in target cell apoptosis during lymphocyte mediated cytotoxicity. Exocytosis of granzyme containing granules in the cytoplasm of the target cell leads to the induction of DNA fragmentation and apoptosis. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilutions: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C before opening. DO NOT FREEZE! Stable at 4 degrees C as an undiluted liquid. Stable for at least 12 months at 4 degrees C. Freezing R-Phycoerythrin (PE) conjugates will result in a substantial loss of activity. PE conjugates are sensitive to light.
Catalogue number: G8957-15G
Reactivities: Human, Non-Human Primate
Hosts: Mouse
Applications: Flow Cytometry
Size: 100ug
Form: Suppled as a liquid in PBS, 0.1% sodium azide. Labeled with PE.
P type: Mab
Isotype: IgG1
Purity: Purified by affinity chromatography.
References: 1. Phenotypic and functional separation of memory and effector human CD8+ T cells: D. Hamann, et al.; J. Exp. Med. 186, 1407 (1997) 2. The CD8+ granzyme B+ T-cell subset in peripheral blood from healthy individuals contains activated and apoptosis-prone cells: P.C. Wever, et al.; Immunology 93, 383 (1998) 3. Extracellular granzymes A and B in humans: detection of native species during CTL responses in vitro and in vivo: E.H. Spaeny-Dekking, et al.; J. Immunol. 160, 3610 (1998)
Additional info: Recognizes human granzyme B. Species Crossreactivity: chimpanzee and Rhesus monkey.

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