Home  >  Products  >  Granulocyte Macrophage Colony Stimulating Factor (GM-CSF, Burst Promoting Activity, CMCSF, Colony Stimulating Factor 2, CSF Alpha, Eosinophil Colony Stimulating Factor, Granulocyte Macrophage Colony Stimulating Factor, Molgramostin, Pluripoietin Alpha, Sa

Granulocyte Macrophage Colony Stimulating Factor (GM-CSF, Burst Promoting Activity, CMCSF, Colony Stimulating Factor 2, CSF Alpha, Eosinophil Colony Stimulating Factor, Granulocyte Macrophage Colony Stimulating Factor, Molgramostin, Pluripoietin Alpha, Sa

Cat no: G8951-25B


Supplier: United States Biological
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GM-CSF is a 23kD glycoprotein with diverse effects on immune and non-immune cells. It induces differentiation of granulocyte, macrophage and eosinophil precursor cells. Proliferation of monocyte-macrophages, T lymphocytes, keratinocytes and endothelial cells is stimulated by GM-CSF. In addition, GM-CSF alters the functional properties of mature granulocytes, macrophages, eosinophils and basophils. GM-CSF is produced by T lymphocytes, macrophages and several cell types in extramedullary sites, where it may act in a paracrine manner to regulate the local response to antigenic challenge. Applications: Suitable for use in Inhibition, ELISA, Western Blot, Immunoprecipitation, Immunohistochemistry and Flow Cytometry. Other applications not tested. Recommended Dilutions: Inhibition of Biological Activity in vitro: ~2.5ug/ml neutralizes 10ug/ml GM-CSF. Immunohistochemistry: Frozen sections Flow Cytometry: Intrecellular staining of permeabilized cells. Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: G8951-25B
Reactivities: Mouse
Hosts: Rat
Applications: ELISA, Flow Cytometry, Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 100ug
Form: Supplied as a lyophilized powder from PBS. Reconstitute by injection of 500ul sterile ddH2O. Caution: vial is under vacuum.
P type: Mab
Isotype: IgG2a
Purity: Purified by Protein G affinity chromatography.
Alternative names: GM-CSF, colony stimulating factor, sargamostin, granulocyte-macrophage colony stimulating factor
References: 1. O'Garra, A et al; The BCL1 B lymphoma responds to IL-4, IL-5, and GM-CSF. Cell Immunol 1989, 123: 189 2. Ruef, C et al; Granulocyte-macrophage colony-stimulating factor: pleiotropic cytokine with potential clinical usefulness. Rev Infect Dis 1990, 12: 41
Additional info: Recognizes mouse Granulocyte Macrophage Colony Stimulating Factor (GM-CSF). Reacts with natural and recombinant mouse GM-CSF. Inhibits the induction of the proliferation of BCL1 cells by GM-CSF.

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