Home  >  Products  >  Granulocyte Macrophage Colony Stimulating Factor (GM-CSF, Burst Promoting Activity, CMCSF, Colony Stimulating Factor 2, CSF Alpha, Eosinophil Colony Stimulating Factor, Granulocyte Macrophage Colony Stimulating Factor, Molgramostin, Pluripoietin Alpha, Sa
Granulocyte Macrophage Colony Stimulating Factor (GM-CSF, Burst Promoting Activity, CMCSF, Colony Stimulating Factor 2, CSF Alpha, Eosinophil Colony Stimulating Factor, Granulocyte Macrophage Colony Stimulating Factor, Molgramostin, Pluripoietin Alpha, Sa

Granulocyte Macrophage Colony Stimulating Factor (GM-CSF, Burst Promoting Activity, CMCSF, Colony Stimulating Factor 2, CSF Alpha, Eosinophil Colony Stimulating Factor, Granulocyte Macrophage Colony Stimulating Factor, Molgramostin, Pluripoietin Alpha, Sa

Cat no: G8951-10J1

Supplier: United States Biological
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GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages. It promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. It is produced in by endothelial cells, monocytes, fibroblasts and T lymphocytes. GM-CSF inhibits neutrophil migration and enhances the functional activity of the mature end-cells. The human and murine molecules are species-specific and exhibit no cross-species reactivity. Applications: Suitable for use in ELISA, Immunofluorescence and Flow Cytometry. Other applications not tested. Recommended Dilution: Immunofluorescence: Useful for intracytoplasmic staining. Flow Cytometry: Identifies GM-CSF-positive cells within mixed cell populations. Optimal dilutions to be determined by the researcher. Control: I1904--82L4: Rat IgG2a Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: G8951-10J1
Reactivities: Human
Hosts: Rat
Applications: ELISA, Flow Cytometry, Immunofluorescence
Size: 500ug
Form: Supplied as a liquid in 100mM borate buffered saline, pH 8.0. No preservatives or amine-containing buffer salts added.
P type: Mab
Isotype: IgG2a
Purity: Purified
References: 1. Abrams, J.S., M.-G. Roncarolo, H.. Yssel, U. Andersson, G.J. Gleich, and J.E., Silver. 1992. Strategies of anti-cytokine monoclonal antibody development: Immunoassay of IL-10 and IL-5 in clinical samples. Immunol. Rev. 127:5-24. 2. Abrams, J., J. Silver, R. van Dyke, and G. Gleich. 1994. Eosinophil-active cytokines in human disease: Development and use of monoclonal antibodies to IL-3-, IL-5, GM-CSF. In Eosinophils in Allergy and Inflammation (A. Kay and G. Gleich, eds). Marcel Dekker, New York, pp. 133-157. 3. Bacchetta, R., T. de Wall Malefyt, H. Yssel, J.S. Abrams, J.E. de Vries, H. Spits, and M.G. Roncarolo. 1990, Host reactive CD4+ and CD8+ T cells clones isolated from a human chimera produce IL-5, Il-2, IFN-gamma and granulocyte/macrophage stimulating factor bit not IL-4. J. Immunol. 144:902-908. 4. Kita, H., T. Ohnishi, Y. Okubo, D. Weller, J.S. Abrams, and G.J. Gleich. 1991. GM-CSF and interleukin-3 release by human peripheral blood eosinophils and neutrophils. J. Exp. Med. 174:745-748.
Additional info: Recognizes human granulocyte/macrophage colony stimulating factor (GM-CSF). Species Crossreactivity: (reported) Rhesus monkey.

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