Fibrillarin Antibody

Cat no: 253136

Supplier: ABBIOTEC

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Description
Additional Information

Fibrillarin is a nucleolar protein involved in the processing of pre-18S ribosomal RNA. Nop1p is the yeast homologue of a protein found in all eukaryotes and archea generally called fibrillarin. Fibrillarin/Nop1p is e, Xenopus/Amphibian,traordinarily conserved, so that the yeast and human proteins are 67% identical, and the human protein can functionally replace the yeast protein. Patients with the autoimmune disease scleroderma often have strong circulating autoantibodies to a ~34kDa protein which was subsequently found to be fibrillarin. Recent studies show that knock-out of the fibrillarin gene in mice results in embryonic lethality, although mice with only one functional fibrillarin/Nop1p gene were viable.

Catalogue number:	253136
Reactivities:	Human, Rabbit
Applications:	Immunofluorescence
Size:	0.1 ml
Accession:	P15646
Antigen:	Yeast nuclear preparations.
Format:	Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of HEPES (pH7.5), 0.01% BSA, with 50% glycerol with 0.065% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type:	Mouse Monoclonal Antibody
Isotype:	Mouse IgG1
Clonality:	38F3
Additional info:	rRNA 2'-O-methyltransferase fibrillarin; U3 small nucleolar RNA-associated protein NOP1; Nucleolar protein 1; U3 snoRNA-associated protein NOP1; NOP1