Cell-permeable. Blocks adipogenesis by inhibiting the activation of SREBPs (Sterol Regulatory Binding Proteins). Inhibits the ER-Golgi translocation of SREBPs via binding to their escort protein (SCAP). Prevents increases in body weight, blood glucose and hepatic fat accumulation in obese ob/ob mice.
Sequence:
2-(2-propylpyridin-4-yl)-4-(p-tolyl)thiazole
Molecular Weight:
~294.41
Solubility:
DMSO (~25mg/ml)
Storage and Stability:
Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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