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Fas Ligand (FASL) (Biotin)

Cat no: F0019-66S

Supplier: United States Biological
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Application(s): Flow Cytometry Immunocytochemistry Western Blot For immunohistochemistry, we recommend MAb to FasL (A11). For the detection of human FasL by flow cytometry or Western blot, we recommmend MAb to FasL (human) (Mike-1) and MAb to FasL (human) (Mike-2).
Catalogue number: F0019-66S
Reactivities: Mouse
Hosts: Rat
Applications: Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot
Conjugates: Biotin
Size: 100Tests
Form: Liquid. Purified antibody in PBS containing 0.02% sodium azide.
P type: Mab
Isotype: IgG2a
Purity: (same/more than)95% (by SDS-PAGE).
References: Product Specific Literature References 1. Characterization of the non-functional Fas ligand of gld mice: M. Hahne, et al.; Int. Immunol. 7: 1381 (1995). 2. CD4+ T cells reactivated with superantigen are both more sensitive to FasL-mediated killing and express a higher level of FasL: J.K. Wang, et al.; Cell. Immunol. 179: 153 (1997). 3. Transgenic expression of CD95 ligand on thyroid follicular cells confers immune privilege upon thyroid allografts: L. Tourneur, et al.; J. Immunol. 167: 1338 (2001). GENERAL LITERATURE REFERENCES 1. Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide: H. Russell, et al.; PNAS 90: 4409 (1993), 2. Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways: B. Lowin, et al.; Nature 370: 650 (1994). 3. A role for CD95 ligand in preventing graft rejection: D. Bellgrau, et al.; Nature 377: 630 (1995). 4. Fas ligand-induced apoptosis as a mechanism of immune privilege: T.S. Griffith, et al.; Science 270: 1189 (1995). 5. Apoptosis by death factor: S. Nagata; Cell 88: 355 (1997).
Additional info: Recognizes mouse FasL.

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