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Fas (CD95, APO-1) (PE/CY5)

Fas (CD95, APO-1) (PE/CY5)

Cat no: F0019-59Z5

Supplier: United States Biological
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CD95, also known as Fas and Apo-1, is a 40-50kD type I transmembrane glycoprotein and a member of the tumor necrosis factor receptor superfamily. It is expressed by activated lymphocytes, monocytes, neutrophils, fibroblasts and cell lines. Fas ligand binding to CD95 induces apoptosis in activated mature lymphocytes thereby playing a role in maintaining peripheral tolerance. PE/CY5 combination conjugate is used as a third fluorochrome in multicolor flow cytometry applications when only a single 488nm excitation source is available. Antibodies are covalently coupled using heterobifunctional linking reagents, resulting in an optimal conjugation format for flow cytometry. Applications: Suitable for use in Flow cytometry, Immunohistochemistry, Immunoprecipitation and In vitro induction of apoptosis. Other applications have not been tested. Recommended Dilutions: Flow Cytometry: 10ul/10e6 cells Immunohistochemistry: frozen sections Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C before opening. DO NOT FREEZE! Stable for 12 months at 4 degrees C. Freezing PE/CY5 conjugates will result in a substantial loss of activity. PE/CY5 conjugates are sensitive to light.
Catalogue number: F0019-59Z5
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Immunohistochemistry, Immunoprecipitation
Size: 100Tests
Form: Supplied as a liquid in PBS, 0.1% sodium azide and a stabilizing agent. Labeled with PE/CY5.
P type: Mab
Isotype: IgG2a
Purity: Purified
References: 1. Schlossman, S., L. Bloumsell, W. Gilks, J.M. Harlan, C. Kishimoto, J. Ritz, S. Shaw, R. Silverstein, T.\ Springer, T.F. Tedder, and R.F. Todd, eds. 1995. Leukocyte Typing V: White Cell Differentiation Antigens, Oxford University Press, Oxford. 2. Kishimoto, T., A.E.G. von dern Borne, S.M. Goyert, D.Y. Mason, M. Miyasaka, L. Moretta, K. Okumura, S. \ Shaw, T.A. Springer, K. Sugamura, and H. Zola, eds. 1998. Leukocyte Typing VI: White Cell Differentiation Antigens, Academic Press, New York. 3. Barclay, A.N., M.H. Brown, S.K.A. Law, A.J. McKnight, M.G. Tomlinson, and P.A. van der Merwe, eds. 1997. The Leukocyte Antigens Facts Book, 2nd Edition, CD95 Section, Academic Press, New York, p. 363. 4. Nagata, S., and P. Golstein. 1995. Science 267:3378. 5. van Parijs, L., and A.K. Abbas. 1996. Curr. Opin. Immunol. 8:355.
Additional info: Recognizes human Fas (CD95, APO-1).

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