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Fas (CD95, APO-1) (Biotin)

Cat no: F0019-62D

Supplier: United States Biological
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Application(s): Immunohistochemistry (frozen sections): This product is an isotype-switch variant of the original clone. Since undesired side reactions in immunohistochemistry are minimal for IgG1 antibodies, this clone is especially useful for immunohistology on cryostat sections and on cytospin preparations [1]. Note: Not suitable for stainings on paraffin sections. Flow Cytometry: 1:20 Functional Application: Induces apoptosis upon cross-linking [2]. Optimal conditions must be determined individually for each application.
Catalogue number: F0019-62D
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Immunohistochemistry
Conjugates: Biotin
Size: 100Tests
Form: Liquid. Antibody in 1ml 50mM TRIS, pH 7.4, containing 100mM sodium chloride, 1% BSA and 0.02% sodium azide.
P type: Mab
Isotype: IgG1
Purity: Highly purified (SDS-PAGE).
References: 1. Constitutive and induced expression of APO-1, a new member of the nerve growth factor/tumor necrosis factor receptor superfamily, in normal and neoplastic cells: F. Leithauser, et al.; Lab. Invest. 69, 415 (1993) 2. Activation of Fas by FasL induces apoptosis by a mechanism that cannot be blocked by Bcl-2 or Bcl-x(L): D.C. Huang, et al.; PNAS 96, 14871 (1999) 3. Inhibition of death receptor-mediated gene induction by a cycloheximide-sensitive factor occurs at the level of or upstream of Fas-associated death domain protein (FADD): H. Wajant, et al.; J. Biol. Chem. 275, 24357 (2000)
Additional info: Recognizes human Fas.

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