FAB3C belongs to the FAM3 family and contains a GG domain. A change in expression of this protein has been noted in pancreatic cancer-derived cells. Fam3c may be a downstream target gene for the Nkx5.1 transcription factor, and may thus be involved in cell differentiation and proliferation during inner ear embryogenesis. Also, it may be involved in retinal laminar formation and promotes epithelial to mesenchymal transition.
Source:
Recombinant corresponding to aa25-227 from human FAM3C, fused to His-tag at N-terminal expressed in E.coli.
AA Sequence:
MGSSHHHHHH SSGLVPRGSH MQVFEIKMDA SLGNLFARSA LDTAARSTKP PRYKCGISKA CPEKHFAFKM ASGAANVVGP KICLEDNVLM SGVKNNVGRG INVALANGKT GEVLDTKYFD MWGGDVAPFI EFLKAIQDGT IVLMGTYDDG ATKLNDEARR LIADLGSTSI TNLGFRDNWV
FCGGKGIKTK SPFEQHIKNN KDTNKYEGWP EVVEMEGCIP QKQD
Molecular Weight:
~24.5kD (MALDI-TOF)
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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