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Epidermal Growth Factor Receptor (erbB, EGFR) (APC)

Cat no: E3375-01B1

Supplier: United States Biological
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The epidermal growth factor receptor (EGF R) subfamily of receptor tyrosine kinases comprises four members: EGF R (also known as HER1, ErbB1 or ErbB), ErbB2 (Neu, HER-2), ErbB3 (HER-3), and ErbB4 (HER-4). All family members are type I transmembrane glycoproteins that have an extracellular domain containing two cysteine-rich domains separated by a spacer region that is involved in ligand-binding, and a cytoplasmic domain that has a membrane-proximal tyrosine kinase domain, and a C-terminal tail with multiple tyrosine autophosphorylation sites. The human EGFR gene encodes a 1210 amino acid (aa) residue precursor with a 24 aa putative signal peptide, a 621 aa extracellular domain, a 23 aa transmembrane domain, and a 542 aa cytoplasmic domain. EGF R has been shown to bind a subset of the EGF family ligands, including EGF, amphiregulin, TGF-alpha, betacellulin, epiregulin, heparin-binding EGF, and neuregulin-2 alpha, in the absence of a co-receptor. Ligand binding induces EGF R homodimerization as well as heterdimerization with ErbB2, resulting in kinase activation, tyrosine phosphorylation, and cell signaling. EGF R can also be recruited to form heterodimers with the ligand-activated ErbB3 or ErbB4. EGF R signaling has been shown to regulate multiple biological functions including cell proliferation, differentiation, motility and apoptosis. In addition, EGF R signaling has also been shown to play a role in carcinogenesis.1-3 Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: Store at 4 degrees C before opening. DO NOT FREEZE. This product is stable at 4 degrees C as an undiluted liquid. Dilute only prior to immediate use. Protect from light.
Catalogue number: E3375-01B1
Reactivities: Human
Hosts: Rat
Applications: Flow Cytometry
Size: 100Tests
Form: Supplied as a liquid in PBS, 0.1% sodium azide. Labeled with APC.
P type: Mab
Isotype: IgG2a
Purity: Purified by Protein G affinity chromatography.
Alternative names: EC=, ERBB1, MENA
References: 1. Daly, R.J., (1999) Growth Factors, 16:255-263. 2. Schlessinger, J., (2000) Cell. 103:211-225. 3. Maihle, N.J. et al., (2002) Cancer Treat. Res. 107:247-258.
Additional info: Recognizes human EGFR.

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