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Enniatin B

Cat no: E3222-28

Supplier: United States Biological
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Enniatins are a complex of family produced several Fusarium species. The enniatins have been shown to act as ionophores. More recently their effects on acyl-CoA cholesterol transferase, transporters and the selectivity of their antitumor action have received more focus. Enniatin B is the most studied of four major analogues of the enniatin complex. Source: Enniatin B Molecular Weight: ~639.8 Solubility: Soluble in ethanol, methanol, DMF or DMSO. Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with ethanol, methanol, DMF or DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: E3222-28
Size: 1mg
Form: Supplied as a white powder.
Purity: (same/more than) 95% by HPLC
References: 1. Ionophore antibiotics produced by the fungus Fusarium orthoceras var. enniatum and other Fusaria. Gaumann, E., et al., Experientia 3: 202 (1947). 2. "Sandwich" complexation in cyclopeptides and its implications in membrane processes. Ivanov, V.T., Ann. N.Y. Acad. Sci. 264: 221 (1975). 3. Interaction of cyclic peptides and depsipeptides with calmodulin. Mereish, K.A., et al., Pept. Res. 3: 233 (1990). 4. Enniatin has a new function as an inhibitor of Pdr5p, one of the ABC transporters in Saccharomyces cerevisiae. Hiraga, K., et al., Biochem. Biophys. Res. Commun. 328: 1119 (2005). 5. Enniatin exerts p53-dependent cytostatic and p53-independent cytotoxic activities against human cancer cells. Dornetshuber, R., et al., Chem. Res. Toxicol. 20: 465 (2007).

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