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Enniatin A1 (2-(N-Methyl-L-valine) Enniatin A)

Cat no: E3222-27

Supplier: United States Biological
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Enniatins are a family of depsipeptides produced several Fusarium species. The enniatins have been shown to act as ionophores. More recently their effects on acyl-CoA cholesterol transferase, transporters and the selectivity of their antitumor action have received more focus. Enniatin A1 is one of four major analogues of the enniatin complex and has previously not been available for investigation. Source: Enniatin A1 Molecular Weight: ~667.9 Solubility: Soluble in ethanol, methanol, DMF or DMSO. Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with ethanol, methanol, DMF or DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: E3222-27
Size: 1mg
Form: Supplied as a white powder.
Purity: (same/more than) 95% by HPLC
Alternative names: 2-(N-Methyl-L-valine) Enniatin A
References: 1. Ionophore antibiotics produced by the fungus Fusarium orthoceras var. enniatum and other Fusaria. Gaumann, E., et al., Experientia 3: 202 (1947). 2. "Sandwich" complexation in cyclopeptides and its implications in membrane processes. Ivanov, V.T., Ann. N.Y. Acad. Sci. 264: 221 (1975). 3. Interaction of cyclic peptides and depsipeptides with calmodulin. Mereish, K.A., et al., Pept. Res. 3: 233 (1990). 4. Enniatin has a new function as an inhibitor of Pdr5p, one of the ABC transporters in Saccharomyces cerevisiae. Hiraga, K., et al., Biochem. Biophys. Res. Commun. 328: 1119 (2005). 5. Enniatin exerts p53-dependent cytostatic and p53-independent cytotoxic activities against human cancer cells. Dornetshuber, R., et al., Chem. Res. Toxicol. 20: 465 (2007).

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