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DNA (cytosine-5) methyltransferase 1 (Dnmt1), Active

Cat no: 10-201


Supplier: B-Bridge International, Inc.
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DNA methylation is significant for epigenetic regulation of gene expression, X chromosome inactivation, genomic imprinting, and development. Abberant methylation patterns are associated with certain human tumors and developmental abnormalities. In vertebrates, there are two types of DNA methyltransferase activities; de novo and maintenance types. Two DNA methyltransferases, Dnmt3a and Dnmt3b, are responsible for the creation of methylation patterns at an early stage of embryogenesis (de novo-type), while Dnmt1 is responsible for the maintenance of methylation patterns during replication. Dnmt1 favors to methylate the hemimethylated DNA and preferentially methylates one strand of the double-stranded DNA during its processive methylation. This product, mouse Dnmt1 deleting the N-terminal 290 amino acid residues, was expressed using a baculovirus expression system and purified by Prof. S. Tajima and Dr. I. Suetake of Osaka University (ref.2). Applications 1) In vitro metylation of cytosine residues in hemimethylated DNA at 5'
Catalogue number: 10-201
Size: 300 units

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