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Dkk2 (Dickkopf-related Protein 2, Dickkopf-2, Dkk-2, mDkk-2)

Dkk2 (Dickkopf-related Protein 2, Dickkopf-2, Dkk-2, mDkk-2)

Cat no: D3795-03F

Supplier: United States Biological
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Xenopus Dickkopf (Dkk)-1 was initially discovered as a Wnt antagonist that plays an important role in head formation. By far, four members of Dkk have been identified in mammals. Each Dkk molecule contains two conserved cysteine-rich domains. Recent studies showed that the second Cys-rich domains of Dkk1 and Dkk2 inhibited Wnt-3a-activated signaling, whereas the first Cysrich domains had no effects. In addition, the second Cys-rich domain of Dkk-2, but not that of Dkk- 1, was able to activate the canonical pathway in the presence of LRP6, and this LRP-dependent signaling does not require Dvl. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-4ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: D3795-03F
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.5% BSA, 0.01% thimerosal, 30% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by affinity chromatography.
Additional info: Recognizes mouse Dkk2 at ~57kD. A ~55kD and ~28kD Dkk2 fragments can also be detected in rat kidney tissue lysate. Species Crossreactivity: human and rat.

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