Home  >  Products  >  DFF45 (DNA Fragmentation Factor 45kD Subunit, DFF 45, DFF-45, DFF1, DNA Fragmentation Factor Subunit alpha, DFFA, H13, Inhibitor of CAD, ICAD)
DFF45 (DNA Fragmentation Factor 45kD Subunit, DFF 45, DFF-45, DFF1, DNA Fragmentation Factor Subunit alpha, DFFA, H13, Inhibitor of CAD, ICAD)

DFF45 (DNA Fragmentation Factor 45kD Subunit, DFF 45, DFF-45, DFF1, DNA Fragmentation Factor Subunit alpha, DFFA, H13, Inhibitor of CAD, ICAD)

Cat no: D3224-10Q

Supplier: United States Biological
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During apoptosis, various stimuli activate a protease cascade of caspases that eventually cause degradation of chromosomal DNA. DFF45 (DNA fragmentation factor 45) is a down-stream regulator of DNA degradation (DFF40). DFF40 is an apoptotic DNase with a high specific activity that exists in an inactive complex with DFF45 in living cells. Cleavage of DFF45, which is mediated by caspase-3, leads to DFF40 release where it then enters nucleus to function as a nuclease. DFF45 may inhibit the DNAse activity of DFF40 and its nuclear translocation. Activation of DFF40 causes DNA degradation, a hallmark of apoptosis. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-4ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: D3224-10Q
Reactivities: Human
Hosts: Mouse
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.5% BSA, 0.02% thimerosal, 50% glycerol.
P type: Mab
Isotype: IgG1
Purity: Purified by affinity chromatography.
Additional info: Recognizes human DFF45-GST at ~40kD and ~45kD.

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