Home  >  Products  >  DEDAF (RING1 and YY1-binding Protein, Apoptin-associating Protein 1, APAP-1, Death Effector Domain-associated Factor, DED-associated Factor, YY1 and E4TF1-associated Factor 1, RYBP, YEAF1)

DEDAF (RING1 and YY1-binding Protein, Apoptin-associating Protein 1, APAP-1, Death Effector Domain-associated Factor, DED-associated Factor, YY1 and E4TF1-associated Factor 1, RYBP, YEAF1)

Cat no: D1882-01J


Supplier: United States Biological
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Cell death signal are transduced by death domain (DD), death effector domain (DED), and caspase recruitment domain (CARD) containing molecules. A novel protein that interacts with DED of caspase-8 and -10, and FADD was recently identified and designated DEDAF (for DED associated factor). DEDAF is identical to the transcriptional repressor RYBP. DEDAF interacts with FADD and augments the formation of CD95/FADD/caspase-8 complexes at the cytoplasm. DEDAF also interacts with DED-containing DNA biding protein (DEDD) in the nucleus, indicating it is involved in the regulation of both cytoplasmic and nuclear events of apoptosis. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-4ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: D1882-01J
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.5% BSA, 0.01% thimerosal, 30% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by affinity chromatography.
Additional info: Recognizes human DEDAF at ~32kD. Species Crossreactivity: mouse and rat.

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