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Cysteine-Rich Secretory Protein 3 (CRISP3)

Cat no: C9018-58B

Supplier: United States Biological
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CRISP-3 belongs to the large CRISP family of secreted proteins with a characteristic C-terminal cysteine-rich (CR) domain. Members of the CRISP family contain three conserved domains: a plant pathogenesis related group 1 (PR-1) domain, a short hinge region, and a CR domain. CRISP-3 is expressed in salivary glands, prostate, pancreas, and in the secretory granules of neutrophilic granulocytes. In plasma, CRISP-3 circulates in a complex with alpha B-glycoprotein, a member of the Ig superfamily. CRISPs are characterized by a cysteine-rich domain at the COOH terminal that form 8 intramolecular disulfide bonds. Mammalian members of the CRISP family are expressed predominantly in the male reproductive tract and are implicated in the process of reproduction from spermiogenesis, post-testicular sperm maturation and capacitation to oocyte-sperm fusion. CRISP3 is epithelium-specific and found predominantly in salivary gland, pancreas and prostate, and in less abundance in the epididymis, ovary, thymus and colon. CRISP3 is up-regulated in malignant prostatic epithelium, therefore, it can be used as a potential prostate cancer biomarker. Applications: Suitable for use in ELISA and Flow Cytometry. Other applications not tested. Recommended Dilution: ELISA (competitive): 1:200-1:400 Flow Cytometry: 1.2ug per 10e6 cells Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C9018-58B
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Flow Cytometry
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2
P type: Mab
Isotype: IgG1
Purity: Purified by Protein G affinity chromatography
References: 1. Kra?tzschmar J, Haendler B, Eberspaecher U, Roosterman D, Donner P, Schleuning WD (1996). The human cysteine-rich secretory protein (CRISP) family. Primary structure and tissue distribution of CRISP-1, CRISP-2 and CRISP-3 Eur J Biochem 15;236(3):827-36 2. Udby L, Bjartell A, Malm J, Egesten A, Lundwall A, Cowland JB, Borregaard N, Kjeldsen L (2005). Characterization and Localization of Cysteine-Rich Secretory Protein 3 (CRISP-3) in the Human Male Reproductive Tract. J Androl ;26(3):333-42 3. Kosari F, Asmann YW, Cheville JC and Vasmatzis G (2002). Cysteine-rich Secretory Protein-3: A Potential Biomarker for Prostate Cancer. Cancer Epidemiology Biomarkers & Prevention 11;1419- 1426
Additional info: Recognizes human native CRISP3 expressed on transfected mammalian cells

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