Home  >  Products  >  CSN3 (Constitutive Photomorphogenic Homolog Subunit 3, COP9 (Constitutive Photomorphogenic) Subunit 3, COP9 Complex Homolog Subunit 3, COP9 Complex S3, COP9 Complex Subunit 3, COP9 Constitutive Photomorphogenic Homolog Subunit 3, COP9 Homolog, COP9 Signal
CSN3 (Constitutive Photomorphogenic Homolog Subunit 3, COP9 (Constitutive Photomorphogenic) Subunit 3, COP9 Complex Homolog Subunit 3, COP9 Complex S3, COP9 Complex Subunit 3, COP9 Constitutive Photomorphogenic Homolog Subunit 3, COP9 Homolog, COP9 Signal

CSN3 (Constitutive Photomorphogenic Homolog Subunit 3, COP9 (Constitutive Photomorphogenic) Subunit 3, COP9 Complex Homolog Subunit 3, COP9 Complex S3, COP9 Complex Subunit 3, COP9 Constitutive Photomorphogenic Homolog Subunit 3, COP9 Homolog, COP9 Signal

Cat no: C7945-52B

Supplier: United States Biological
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COPS3 is a component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.Individual subunits of the complex have been linked to various signal transduction pathways leading to gene expression and cell cycle control (1, 2).Subunit 3 (COPS3) possesses kinase activity that phosphorylates regulators involved in signal transduction.It phosphorylates I kappa-B alpha, p105, and c-Jun.It acts as a docking site for complex-mediated phosphorylation (3).COPS3 is suggested as a specific negative regulator of TNF- induced NF-kappaB activation pathways because its over- expression inhibits NF-kappaB activation (4). Applications: Suitable for use in Flow Cytometry, Western Blot, Immunoprecipitation and Immunocytochemistry. Other applications not tested. Recommended Dilution: Flow Cytometry: 1:20 Western Blot: 1:10,000-1:20,000 Immunoprecipitation: 1:40 Immunocytochemistry: 1:250-1:500 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Manufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Catalogue number: C7945-52B
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Flow Cytometry, Immunocytochemistry, Immunoprecipitation, Western Blot
Size: 100ul
Form: Supplied as a liquid in 50mM Tris-Glycine (pH 7.4), 0.15M sodium chloride, 40% glycerol, 0.01% sodium azide and 0.05% BSA.
P type: Mab
Isotype: IgG
Purity: Supernatant
Alternative names: JAB-1-containing Signalosome Subunit 3
References: 1. Tsuge T, et al. J Mol Biol. 305(1):1-9, 2001 2. Fang L., et al. J. Proteome Res. 7:4914-4925, 2008 3. The UniProt Consortium, The Universal Protein Resource (UniProt), Nucleic Acids Res. 36:D190-D195, 2008 4. Hong X, et al. FEBS Lett. 499(1-2):133-6, 2001
Additional info: Recognizes human COPS3. Species Crossreactivity: Mouse and rat.

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