Home  >  Products  >  Crk p38 phosphorylated, (Tyr221) (Adapter molecule crk, Avian sarcoma virus CT10 (v crk) oncogene homolog, CRK isoform 2, CRK isoform II, CRKII, p38Proto oncogene C crk, v crk avian, Sarcoma virus CT10 oncogene homolog, v crk Sarcoma virus CT10 oncogene h

Crk p38 phosphorylated, (Tyr221) (Adapter molecule crk, Avian sarcoma virus CT10 (v crk) oncogene homolog, CRK isoform 2, CRK isoform II, CRKII, p38Proto oncogene C crk, v crk avian, Sarcoma virus CT10 oncogene homolog, v crk Sarcoma virus CT10 oncogene h

Cat no: C7924-10C


Supplier: United States Biological
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Crk (p38) are adaptor proteins, composed mostly of SH2 and SH3 domains, which play a key role in cellular signaling by mediating the construction of protein complexes and also by managing cell proliferation, differentiation, and migration (1). They are critical integrators of upstream signals for cell invasion and migration in human cancer cell lines. Crk is believed to be a regulator of invasive responses because increased levels of the protein have been observed in multiple human cancers (2). In vivo studies have demonstrated that decreased levels of Crk remarkably inhibits tumor formation and its invasive growth (3). Crk associates with ERM family proteins (including ezrin, radixin, and moesin), activates RhoA, and promotes cell motility toward hyaluronic acid (4). Applications: Suitable for use in Immunocytochemistry, Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1000-2000 Immunocytochemistry: 1:50 -10 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Manufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Catalogue number: C7924-10C
Reactivities: Human
Hosts: Rabbit
Applications: Immunocytochemistry, Western Blot
Size: 100ul
Form: Supplied as a liquid in 50mM Tris-glycine, pH 7.4, 0.15M sodium chloride, 40% glycerol, 0.01% sodium azide, 0.05% BSA.
P type: Mab
Isotype: IgG
Purity: Supernatant
References: 1. Nishihara H, et al. Cancer Lett (1):55-61, 2002. 2. Watanabe T, et al. Mol Cancer Res. (7):499-510, 2006. 3. Rodrigues SP, et al. Mol Cancer Res. (4):183-94, 2005. 4. Tsuda MJ, et al. Biol Chem. (45):46843-50, 2004.
Additional info: Recognizes human Crk/p38 protein when phosphorylated at Tyr211.

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