Citrinin is a quinonemethine mycotoxin produced by diverse fungal genera, including Aspergillus and Penicillium. Citrinin has been extensively investigated. It is a potent nephrotoxin with hepatoxic and teratogenic activity. It is the causative agent of Balkan nephropathy and yellow rice fever in humans. At the molecular level, citrinin exhibits a range of effects including free radical damage to DNA and disruption to a wide variety of mitochrondrial membrane-bound enzymic activities and structural integrity. Specifically, citrinin is an inhibitor of NADH dehydrogenase in the mitochondrial electron transport chain and this action is responsible for recent reports of citrinin's apoptotic activity.
Citrinin from Penicillium citrinum.
Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
Storage and Stability:
Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.