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Chromogranin A (CGA, CHG A, Pancreastatin, Parathyroid secretory protein 1, Pituitary secretory protein I, Vasostatin, SPI)

Cat no: C5069-96K


Supplier: United States Biological
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Chromogranin A (CgA) is a 49kD protein which is a member of the granin/secretogranin family of acidic glycoproteins. It is specifically expressed in all endocrine and neuroendocrine cells and plays multiple roles in the process of regulated secretion of peptide hormones and neurotransmitters. Owing to its over-expression in several tumors of neuroendocrine origin, CgA is of diagnostic value in classical endocrine, in hormone-negative and in neuroendocrine tumors. Applications: Suitable for use in ELISA and Flow Cytometry. Other applications not tested. Recommended Dilution: ELISA: 1:200-1:400 Flow Cytometry: 1.2ug/1x1056 cells Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C5069-96K
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Flow Cytometry
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2.
P type: Mab
Isotype: IgG1
Purity: Purified by Protein G chromatography.
References: 1. Hendy GN, Bevan S, Mattei MG, Mouland AJ (1995). Chromogranin A. Clin Invest Med;18(1):47-65. 2. Deftos LJ (1991). Chromogranin A: its role in endocrine function and as an endocrine and neuroendocrine tumor marker. Endocr Rev; 12(2):181-7.
Additional info: Recognizes human Chromogranin A.

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