Home  >  Products  >  Cercosporamide


Cat no: C2780-40

Supplier: United States Biological
0 reviews | Write a Review Pencil
Isolated from Cercosporidium henningsii, cercosporamide was originally identified as a host-selective phytotoxin and broad spectrum antifungal agent. More recently cercosporamide was shown to inhibit a cell wall integrity pathway mediated through a serine/threonine protein kinase, Pkc1, that is central to cell wall biosynthesis. It is both potent (IC50 < 50nM) and selective for Pkc1 kinase inhibition. Source: Cercosporamide Molecular Weight: ~331.3 Solubility: Soluble in ethanol, methanol, DMF or DMSO. Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with ethanol, methanol, DMF or DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C2780-40
Size: 500ug
Form: Supplied as a dark tan lyophilisate.
Purity: (same/more than) 95% by HPLC
References: 1. Discovery of cercosporamide, a known antifungal natural product, as a selective Pkc1 kinase inhibitor through high-throughput screening. Sussman, A., et al., Eukaryotic Cell 3: 932 (2004). 2. Cloning and characterization of KNR4, a yeast gene involved in (1,3)-beta-glucan synthesis. Hong, Z., et al., Mol. Cell Biol. 1994, 14: 1017 (1994). 3. The structure and biological activity of cercosporamide from Cercosporidium henningsii. Sugawara, F., et al., J. Org. Chem. 56: 909 (1991).

Get Quote

  • Best Price Guaranteed
  • Quick Response Time
  • Exclusive Promotions
United States Biological
Get a Quote Direct from
United States Biological

By submitting this form you agree to your details being passed to United States Biological for the purpose of generating the best quote*

Button_on Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave