Home  >  Products  >  CD74 (HLA-DR, DHLAG, HLA class II histocompatibility antigen gamma, HLADG, Ia antigen-associated invariant chain, Ia-Gamma, Ii, p33, protein 41 antigen invariant chain) (Biotin)

CD74 (HLA-DR, DHLAG, HLA class II histocompatibility antigen gamma, HLADG, Ia antigen-associated invariant chain, Ia-Gamma, Ii, p33, protein 41 antigen invariant chain) (Biotin)

Cat no: C2430-01C2


Supplier: United States Biological
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CD74 represents a type II integral membrane protein known as MHC Class II-associated invariant chain (Mr 43, 41, 35, 33kD). It is moderately expressed on B cells, and weakly on monocytes and macrophages. CD74 is also found on a subset of activated T cells, Langerhans cells, dendritic cells and some epithelial cells. CD74 may play a role in antigen processing and presentation through intracellular transport and expression of Class II molecules on the cell surface.1-4 Applications:
Catalogue number: C2430-01C2
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Immunohistochemistry, Immunoprecipitation
Conjugates: Biotin
Size: 100Tests
Form: Supplied as a liquid in PBS, 0.1% sodium azide and a stabilizing agent. Conjugated to Biotin.
P type: Mab
Isotype: IgG1
Purity: Purified
Alternative names: CD74 antigen, DHLAG, HLA class II histocompatibility antigen gamma chain, HLADG, HLA-DR antigens-associated invariant chain, Ia antigen-associated invariant chain, Ia-GAMMA, Ii, p33, protein 41
References: 1. Knapp, W., B. Dorken, W.R. GIlks, E.P. Rieber, R.E. Schmidt, H. Stein, A.E.G.K. Von dem Borne, eds. 1989. Leukocyte Typing IV: White Cell Differentiation Antigens, Oxford University Press, Oxford. 2. Barclay, A.N., M.H. Brown, S.K.A. Law, A.J. McKnight, M.G. Tomlinson, and P.A. van der Merwe, eds. 1997. The Leukocyte Antigens Facts Book, 2nd Edition, CD74 Section, Academic Press, New York, p. 327. 3. Lamb, C.A., J.W. Yewdell, J.R. Bennink, and P. Cresswell. 1991. Proc. Natl. Acad. Sci. USA 88:5998. 4. Viville, S., J. Neefjes, V. Lotteau, A. Dierich, M. Lemeur, H. Ploegh, C. Benoist, and D. Mathis. 1993. Cell 72:635.
Additional info: Recognizes human CD74.

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