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CD64 (FcgRI) (FITC)

Cat no: C2419-06J

Supplier: United States Biological
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Human CD64 is a high affinity receptor for monomeric human IgG1 and IgG3 which is expressed on macrophages, monocytes, and gamma interferon induced neutrophils. CD64 plays an important role in clearance of immune complexes and in antibody dependent cytoxicity. CD64, also known as FcgRI, is a 71kD type I transmembrane protein. It is expressed exclusively on monocytes and macrophages and binds monomeric human IgG with high avidity. CD64 is thought to play a role in the antibody-dependent cytotoxicity (ADCC) reactions, phagocytosis and mediates the release of IL-1, IL-6 and TNF-alpha. INF-gamma increases the expression of CD64 and induces its expression on neutrophils which do not usually express CD64. Glucocorticoids have also been reported to increase this receptor. Functional Application: Antibody blocks binding of Fc gamma RI to immunoglobin opsonized cells (1). Applications: Suitable for use in Flow Cytometry and Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, store at -20 degrees C. Aliquots are stable for at least 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C2419-06J
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Western Blot
Size: 120Tests
Form: Supplied as a liquid in PBS, pH 7.2, 5% glycerol, 0.2% BSA, 0.05% sodium azide.
P type: Mab
Isotype: IgG1
Purity: Purified by Protein A affinity chromatography.
References: 1. G.J. Dougherty, et al, (1987) Eur J Immunol 17: 1453-1459. 2. Y. Jayaram, et al, (1989) Clin Exp Immunol 75: 414-420. 3. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 874-875. 4. D.L. Durden, et al, (1995) J Immunol 154: 4039-4047. L.L. Marnell, et al, (1995) 5. J Immunol 155: 2185-2193.
Additional info: Recognizes the CD64 molecule of 72kD from gene Fc gamma RIA.

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