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CD64 (FcgRI) (APC)

Cat no: C2419-05F


Supplier: United States Biological
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CD64, also known as FcgRI, is a 71kD type I transmembrane protein. It is expressed exclusively on monocytes and macrophages and binds monomeric human IgG with high avidity. CD64 is thought to play a role in the antibody-dependent cytotoxicity (ADCC) reactions, phagocytosis and mediates the release of IL-1, IL-6 and TNFalpha. INF-gamma increases the expression of CD64 and induces its expression on neutrophils which do not usually express CD64. Glucocorticoids have also been reported to increase this receptor.1-7 Applications: Suitable for use in Flow Cytometry, Immunohistochemistry, Immunoprecipitation, Western Blot and Blocking Studies. Other applications not tested. Recommended Dilution: Flow Cytometry: 5ul/10e6 cells Immunohistochemistry: Frozen sections Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C. For long-term storage, aliquot and store at 4 degrees C. Do not freeze. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C2419-05F
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 100Tests
Form: Supplied as a liquid in PBS, 0.1% sodium azide and a stabilizing agent. Conjugated to APC.
P type: Mab
Isotype: IgG1
Purity: Purified
References: 1. Schlossman, S., L. Bloumsell, W. Gilks, J.M. Harlan, C. Kishimoto, J. Ritz, S. Shaw, R. Silverstein, T. Springer, T.F. Tedder, and R.F. Todd, eds. 1995. Leukocyte Typing V: White Cell Differentiation Antigens, Oxford University Press, Oxford. 2. Barclay, A.N., M.H. Brown, S.K.A. Law, A.J. McKnight, M.G. Tomlinson, and P.A. van der Merwe, eds. 1997. The Leukocyte Antigens Facts Book, 2nd Edition, CD64 Section, Academic Press, New York, p. 306. 3. Dougherty, G.J., Y. Selvendran, S. Murdoch, D.G. Palmer, and N. Hogg. 1987. Eur. J. Immunol. 17:1453. 4. Jayaram, Y., A.M. Buckle, and N. Hogg. 1989. Clin. Exp. Immunol. 75:414. 5. Ernst, L.K., J.G. van de Winkel, I.-M. Chiu, and C.L. Anderson. 1992. J. Biol. Chem. 267:15692. 6. Perussia, B., E.T. Dayton, R. Lazarus, V. Fanning, and G. Trinchieri. 1983. J. Exp. Med. 158:1092. 7. Inkeless, J.C. 1989. J. Clin. Invest. 83:355.
Additional info: Recognizes human CD64.

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