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CD56 (NCAM-1, Neural Cell Adhesion Molecule) (PE/CY5)

Cat no: C2410-76E

Supplier: United States Biological
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CD56, an isoform of the neural cell adhesion molecule (NCAM), is a 220kD heavily glycosylated type I transmembrane protein. On human hematopoietic cells, its expression is restricted to NK cells and a subpopulation of T lymphocytes (known as large granular lymphocytes) which demonstrate natural killer activity. While it is clear that NCAM plays a role in homotypic adhesion of neuronal cells, the significance of CD56 expression on NK cells is not clear and remains controversial.1-4 Applications:
Catalogue number: C2410-76E
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry
Size: 100Tests
Form: Supplied as a liquid in PBS, 0.1% sodium azide and a stabilizing agent. Conjugated to PE/CY5.
P type: Mab
Isotype: IgG2a
Purity: Purified
References: 1. Schlossman, S., L. Bloumsell, W. Gilks, J.M. Harlan, C. Kishimoto, J. Ritz, S. Shaw, R. Silverstein, T. Springer, T.F. Tedder, and R.F. Todd, eds. 1995. Leukocyte Typing V: White Cell Differentiation Antigens, Oxford University Press, Oxford. 2. Barclay, A.N., M.H. Brown, S.K.A. Law, A.J. McKnight, M.G. Tomlinson, and P.A. van der Merwe, eds. 1997. The Leukocyte Antigens Facts Book, 2nd Edition, CD56 Section, Academic Press, New York, p. 284. 3. Rabinowitz, J.E., U. Rutishauser, and T. Magnuson. 1996. Proc. Natl. Acad. Sci. USA 93:6421. 4. Muller, D., C. Wang, G. Skibo, N. Toni, H. Cremer, V. Calaora, G. Rougon, and J.Z. Kiss. 1996. Neuron 17:413.
Additional info: Recognizes human CD56.

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