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CD56 (NCAM-1, Neural Cell Adhesion Molecule) (FITC)

CD56 (NCAM-1, Neural Cell Adhesion Molecule) (FITC)

Cat no: C2410-76B

Supplier: United States Biological
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CD56, an isoform of the neural cell adhesion molecule (NCAM), is a 220kD heavily glycosylated type I transmembrane protein. On human hematopoietic cells, its expression is restricted to NK cells and a subpopulation of T lymphocytes (known as large granular lymphocytes) which demonstrate natural killer activity. While it is clear that NCAM plays a role in homotypic adhesion of neuronal cells, the significance of CD56 expression on NK cells is not clear and remains controversial. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilutions: Flow Cytometry: 10ul/10e6 cells Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2410-76B
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry
Size: 100Tests
Form: Supplied as a liquid in PBS, 0.1% sodium azide. Labeled with Fluorescein isothiocyanate (FITC).
P type: Mab
Isotype: IgG2a
Purity: Purified
References: 1. Schlossman, S., L. Bloumsell, W. Gilks, J.M. Harlan, C. Kishimoto, J. Ritz, S. Shaw, R. Silverstein, T. Springer, T.F. Tedder, and R.F. Todd, eds. 1995. Leukocyte Typing V: White Cell Differentiation Antigens, Oxford University Press, Oxford. 2. Barclay, A.N., M.H. Brown, S.K.A. Law, A.J. McKnight, M.G. Tomlinson, and P.A. van der Merwe, eds. 1997. The Leukocyte Antigens Facts Book, 2nd Edition, CD56 Section, Academic Press, New York, p. 284. 3. Rabinowitz, J.E., U. Rutishauser, and T. Magnuson. 1996. Proc. Natl. Acad. Sci. USA 93:6421. 4. Muller, D., C. Wang, G. Skibo, N. Toni, H. Cremer, V. Calaora, G. Rougon, and J.Z. Kiss. 1996. Neuron 17:413.
Additional info: Recognizes human CD56.

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