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CD51/CD61 Integrin alphaV beta3 (RGD-dependent Vitronectin Receptor) (FITC)

Cat no: C2405-17K

Supplier: United States Biological
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CD51/61, also known as the alphaVbeta3 integrin and the vitronectin receptor, is a heterodimeric cell surface glycoprotein complex. It is expressed in high amounts on osteoclasts, endothelial cells and melanoma cells. CD51/61 is also found on activated T cells, mast cells, platelets and NK cells. Ligands for CD51/61 include vitronectin, fibronectin, laminin, thrombospondin and von Willebrand-factor. It also mediates cell to cell adhesion via its association with CD31/PECAM-1(1-9). Applications: Suitable for use in Flow Cytometry, Immunohistochemistry, Immunoprecipitation and blocking of Adhesion. Other applications have not been tested. Recommended Dilution: Flow Cytometry: Neat. Use 20ul/10e6 cells Immunohistochemistry: frozen sections Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Store at -20 degrees C or colder. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C2405-17K
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Immunohistochemistry, Immunoprecipitation
Size: 100Tests
Form: Supplied as a liquid in PBS, 0.1% sodium azide and a stabilizing agent. Conjugated to FITC.
P type: Mab
Isotype: IgG1
Purity: Purified
References: 1. Schlossman, S., L. Bloumsell, W. Gilks, J.M. Harlan, C. Kishimoto, J. Ritz, S. Shaw, R. Silverstein, T. Springer, T.F. Tedder, and R.F. Todd, eds. 1995. Leukocyte Typing V: White Cell Differentiation Antigens, Oxford University Press, Oxford. 2. Barclay, A.N., M.H. Brown, S.K.A. Law, A.J. McKnight, M.G. Tomlinson, and P.A. van der Merwe, eds. 1997. The Leukocyte Antigens Facts Book, 2nd Edition, CD51 Section, Academic Press, New York, p. 271. 3. Cheresh, D.A. 1987. Proc. Natl. Acad. Sci. USA 84:6471. 4. Roberts, K., W.M. Yokoyama, P.J. Kehn, and E.M. Shevach. 1991. J. Exp. Med. 173:131. 5. Bianchine, P.J., P.R. Burd, and D.D. Metcalfe. 1992. J. Immunol. 149:3665. 6. Davies, J., J. Warwick, N. Totty, R. Philp, M. Helfrich, and M. Horton. 1989. J. Cell Biol. 109:1817. 7. Rabinowich, H., W.C. Lin, A. Amoscato, R.B. Herberman, and T.L. Whiteside. 1995. J. Immunol. 154:1124. 8. Piali, L., P. Hammel, C. Uherek, F. Bachmann, R.H. Gisler, D. Dunon, and B.A. Imhof. 1995. J. Cell BIol. 130:451. 9. van Leeuwen, R.L., I.G. Yoshinaga, T. Akasaka, S.K. Dekker, B.J. Vermeer, and H.R. Byers. 1996. Exp. Dermatol. 5:308.
Additional info: Recognizes human CD51/CD61.

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