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CD50 (Intercellular Adhesion Molecule, ICAM-3, Lymphocyte Function-Associated Antigen-1, LFA-1) (FITC)

CD50 (Intercellular Adhesion Molecule, ICAM-3, Lymphocyte Function-Associated Antigen-1, LFA-1) (FITC)

Cat no: C2406-15B

Supplier: United States Biological
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CD50 is also known as Inter-cellular adhesion molecule-3 (ICAM-3). CD50 is an 110kD type I transmembrane glycoprotein which is expressed mainly on resting leukocytes. It interacts with lymphocyte function-associated antigen-1 (LFA-1) and DC-SIGN, and is involved in the intercellular adhesion of leukocytes and augments CD3 signalling in T-lymphocyte activation. CD50 expression induces cancer cell proliferation and over-expression may contribute to cancer progression. It has also been implicated in limiting HIV-1 replication. Applications: Suitable for use in Flow Cytometry, ELISA and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Flow Cytometry: 1:20 detected CD50 on HL-60 cells using direct staining. Immunohistochemistry: Can be used to stain both indirectly and directly acetone-fixed cryostat sections or cell smears. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2406-15B
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Flow Cytometry, Immunohistochemistry
Size: 100Tests
P type: Mab
Isotype: IgG1
Purity: Highly purified (SDS-PAGE).
Additional info: Recognizes human CD50 (ICAM-3). Does not cross-react with ICAM-1, ICAM-2 or LFA-1.1/18/12-application table: remove Neut -DF 1/18/12-added concentration, form, -changed purity: Highly purified (SDS-PAGE). -changed grade: Highly Purified -added to specificity: Recognizes human CD50 (ICAM-3). Does not cross-react with ICAM-1, ICAM-2 or LFA-1. -added background from catalog master -changed Application(s): ELISA Flow Cytometry Immunohistochemistry (frozen sections (1.25-0.5ug/ml)) Functional Application (neutralizing) Optimal conditions must be determined individually for each application. -added NEut to application table -changed Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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