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CD49f (Laminin Receptor, Integrin alpha6, VLA alpha6, Platelet gpIc) (PE)

Cat no: C2405-03D

Supplier: United States Biological
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CD49f is the 150kD integrin alpha6 chain which associates noncovalently with the integrin beta1 subunit (CD29) and with the integrin beta4 (CD104) chain to form, respectively, the very late antigen-6 (VLA-6) and alpha6beta4 integrin heterodimers. VLA-6 is expressed on thymocytes, T lymphocytes, monocytes and platelets. CD49f/CD29 expression is upregulated on activated T lymphocytes and memory T cells. VLA-6 serves as the laminin receptor on platelets, monocytes and T cells. VLA-6-mediated binding to laminin provides a costimulatory signal to T cells for activation and proliferation.1-3 Applications:
Catalogue number: C2405-03D
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Immunohistochemistry, Immunoprecipitation
Size: 100Tests
Form: Supplied as a liquid in PBS, 0.1% sodium azide and a stabilizing agent. Conjugated to PE.
P type: Mab
Isotype: IgG2b
Purity: Purified
References: 1. Hemler, M.E. 1990. Annu. Rev. Immunol. 114:365. 2. Barclay, A.N., M.H. Brown, S.K.A. Law, A.J. McKnight, M.G. Tomlinson, and P.A. van der Merwe, eds. 1997. The Leukocyte Antigens Facts Book, 2nd Edition, CD49f Section, Academic Press, New York, p. 267. 3. Tamura, R.N., H.M. Cooper, G. Callo, and V. Quaranta 1991. Proc. Natl. Acad. Sci. USA 88:10183.
Additional info: Recognizes human CD49f.

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