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CD49e (Integrin alpha5) (PE)

Cat no: C2405-01W

Supplier: United States Biological
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CD49e is the integrin alpha5 chain, a 135/25kD heterodimer, that associates noncovalently with CD29, the integrin beta1 subunit, to form the alpha5beta1 very late antigen-5 (VLA-5) complex, a very well established fibronectin receptor that is expressed on many cell types, including thymocytes, T cells, monocytes and platelets. Expression of the VLA-5 heterodimer is increased on activated and memory T cells. It is also found on very early B cells and on activated B lymphocytes. CD49e/CD2-mediated binding to fibronectin provides a costimulatory signal to T cells. It also enhances Fc-gammaR- and complement receptor-mediated phagocytosis, and is involved in monocyte migration into extracellular tissues. Applications: Suitable for use in Flow Cytometry, Immunohistochemistry and Function Blocking. Other applications not tested. Recommended Dilutions: Flow Cytometry: 10ul/10e6 cells Immunohistochemistry: Frozen sections Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C before opening. DO NOT FREEZE! Stable at 4 degrees C as an undiluted liquid. Dilute only prior to immediate use. Stable for at least 12 months at 4 degrees C. Freezing R-Phycoerythrin (PE) conjugates will result in a substantial loss of activity. PE conjugates are sensitive to light.
Catalogue number: C2405-01W
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Immunohistochemistry
Size: 100Tests
Form: Supplied as a liquid in PBS, 0.1% sodium azide and a stabilizing agent. Conjugated to PE.
P type: Mab
Isotype: IgG2b
Purity: Purified
References: 1. Schlossman, S., L. Bloumsell, W. Gilks, J.M. Harlan, C. Kishimoto, J. Ritz, S. Shaw, R. Silverstein, T. Springer, T.F. Tedder, and R.F. Todd, eds. 1995. Leukocyte Typing V: White Cell Differentiation Antigens, Oxford University Press, Oxford. 2. Hemler, M.E. 1990. Annu. Rev. Immunol. 114:365. 3. 155. Barclay, A.N., M.H. Brown, S.K.A. Law, A.J. McKnight, M.G. Tomlinson, and P.A. van der Merwe, eds. 1997. The Leukocyte Antigens Facts Book, 2nd Edition, CD49e Section, Academic Press, New York, p. 265. 4. te Velde, A.A., J.P. Klomp, B.A. Yard, J.E. de Vries, and C.G. Figdor. 1988. J. Immunol. 140:1548. 5. Nermut, M.V., N.M. Green, P. Easton, S.S. Yamada, and K.M. Yamada. 1988. EMBO J. 7:4093. 6. Hynes, R.O. 1992. Cell 69:11.
Additional info: Recognizes human CD49e.

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