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CD40 (FITC)

CD40 (FITC)

Cat no: C2392-02G

Supplier: United States Biological
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Human CD40 is a member of the tumor necrosis factor (TNF) receptor family and is present on all B cells except plasma cells. CD40 is also found on some epithelial cells, carcinomas and lymphoid dendritic cells. CD40 plays an important role in B cell activation and the interaction with its ligand (CD40 Ligand) is essential for isotype switching. Functional Application: Binding of cross linked antibody will partially activate B cells. Applications: Suitable for use in Flow Cytometry and ELISA. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, store at -20 degrees C. Aliquots are stable for at least 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C2392-02G
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Flow Cytometry
Size: 120Tests
Form: Supplied as a liquid in PBS, pH 7.2, 5% glycerol, 0.2% BSA, 0.05% sodium azide.
P type: Mab
Isotype: IgG1
Purity: Purified by Protein A affinity chromatography.
References: 1. C.L. Law, B. Wormann & T.W. LeBien, (1990) Leukemia 4: 732-738. 2. Leukocyte Typing IV (W. Knapp, et al, eds.) Oxford University Press, p. 90-91. 3. W.C. Fanslow, et al, (1992) J Immunol 149: 655-660. 4. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 547-556.
Additional info: Recognizes the CD40 molecule of about 44kD.

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