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CD40 (APC)

Cat no: C2392-04N

Supplier: United States Biological
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CD40, a member of the TNFR-SF, is a 45-48kD type I integral membrane glycoprotein whose ligand is CD154. It is expressed on all mature B lymphocytes, but is absent from plasma cells. It is also present on some epithelial and endothelial cells. CD154 binding to CD40 on B cells is important for T cell/B cell interactions and is required for secondary immune responses. Evidence for a role of CD40-CD154 interaction in negative selection and peripheral tolerance has been suggested. CD40 monoclonal antibodies have been reported to stimulate B cell proliferation when costimulated with anti-mu, CD20 monoclonal antibodies or phorbol esters.1-3 Applications:
Catalogue number: C2392-04N
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry
Size: 100Tests
Form: Supplied as a liquid in PBS, 0.1% sodium azide and a stabilizing agent. Conjugated to APC.
P type: Mab
Isotype: IgG1
Purity: Purified
References: 1. Kishimoto, T., A.E.G. von dern Borne, S.M. Goyert, D.Y. Mason, M. Miyasaka, L. Moretta, K. Okumura, S. Shaw, T.A. Springer, K. Sugamura, and H. Zola, eds. 1998. Leukocyte Typing VI: White Cell Differentiation Antigens, Academic Press, New York. 2. Barclay, A.N., M.H. Brown, S.K.A. Law, A.J. McKnight, M.G. Tomlinson, and P.A. van der Merwe, eds. 1997. The Leukocyte Antigens Facts Book, 2nd Edition, CD40 Section, Academic Press, New York, p. 230. 3. van Kooten, C., and J. Bancherreau. 1996. Adv. Immunol. 61:1.
Additional info: Recognizes human CD40.

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