Home  >  Products  >  CD39 (Apyrase, ATPDase, EC3.6.1.5, Ecto-Apyrase,Ecto-ATPase, ENTPD1, Ectonucleoside triphosphate diphosphohydrolase 1, NTPDase-1, Nucleoside triphosphate diphosphohydrolase 1, Vascular ATP diphosphohydrolase) (APC)

CD39 (Apyrase, ATPDase, EC3.6.1.5, Ecto-Apyrase,Ecto-ATPase, ENTPD1, Ectonucleoside triphosphate diphosphohydrolase 1, NTPDase-1, Nucleoside triphosphate diphosphohydrolase 1, Vascular ATP diphosphohydrolase) (APC)

Cat no: C2391-01E


Supplier: United States Biological
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Ectonucleoside triphosphate diphosphohydrolase-1 (ENTPD1), also known as CD39 or NTPDase-1, was originally described as a B lymphocyte cell surface marker, but it is also present on the surface of natural killer cells, T cells, and some endothelial cells. ENTPD1 hydrolyzes the beta- and gamma-phosphate residues of nucleotides, preferring ATP as the substrate. Through its hydrolysis of extracellular nucleotides, ENTPD1 plays a role in the regulation of purinergic signaling. ENTPD1 is also involved in the processes of thromboregulation and vascular inflammation. The amino acid sequence of human ENTPD1 is 77% and 75% identical to that of mouse and rat. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C before opening. DO NOT FREEZE! Stable at 4 degrees C as an undiluted liquid. Dilute only prior to immediate use. Stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Freezing APC conjugates will result in a substantial loss of activity. APC conjugates are sensitive to light.
Catalogue number: C2391-01E
Reactivities: Human, Mouse
Hosts: Rat
Applications: Flow Cytometry
Size: 100Tests
Form: Supplied as a liquid in PBS, 0.5% BSA and 0.1% sodium azide.
P type: Mab
Isotype: IgG1
Purity: Purified by immunoaffinity chromatography.
References: Enjyoji K et al Targeted disruption of CD39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation. Nature Medicine 5: 1010-1017 (1999); Gayle RB et al Inhibition of platelet function by recombinant soluble ecto-ADPase/CD39. Journal of Clinical Investigation 101: 1851-1859 (1998); Goepfert C et al Disordered cellular migration and angiogenesis in CD39-null mice. Circulation 104(25): 3109-3115 (2001); Kaczmarek E et al Identification and characterization of CD39 vascular ATP diphosphohydrolase. Journal of Biological Chemistry 271: 33116-33122 (1996); Kansas GS et al Expression, distribution and biochemistry of human CD39. Role in activation-associated homotypic adhesion of lymphocytes. Journal of Immunology 146: 2235-2244 (1991); Koziak K et al Palmitoylation targets CD39/endothelial ATP diphosphohydrolase to caveolae. Journal of Biological Chemistry 275: 2057-2062 (2000); Maliszewski CR et al The CD39 lymphoid cell activation antigen. Molecular cloning and structural characterization. Journal of Immunology 153: 3574-3583 (1994); Marcus AJ et al The endothelial cell ecto-ADPase responsible for inhibition of platelet function is CD39. Journal of Clinical Investigation 99: 1351-1360 (1997); Wang TF and Guidotti G CD39 is an ecto-(Ca2+,Mg2+)-apyrase. Journal of Biological Chemistry 271: 9898-9901 (1996); Wang TF and Guidotti G The transmembrane domains of ectoapyrase (CD39) affect its enzymatic activity and quaternary structure. Journal of Biological Chemistry 273: 24814-24821 (1998); Wang TF et al Characterization of brain ecto-apyrase: evidence for only one ecto-apyrase (CD39) gene. Brain Research Molecular Brain Research 47: 295-302 (1997); Wang TF and Guidotti G Widespread expression of ecto-apyrase (CD39) in the central nervous system. Brain Research 790(1-2): 318-322 (1998); Wu JJ et al N-linked oligosaccharides affect the enzymatic activity of CD39: diverse interactions between seven N-linked glycosylation sites. Molecular Biology of the Cell 16(4): 1661-1672 (2005); Zhong X et al Mammalian plasma membrane ecto-nucleoside triphosphate diphosphohydrolase 1, CD39, is not active intracellularly. The N-glycosylation state of CD39 correlates with surface activity and localization. Journal of Biological Chemistry 276: 41518-41525 (2001)
Additional info: Recognizes mouse CD39/ENTPD1.

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