CD38 is a 45kD type II single-chain transmembrane glycoprotein. It is found on immature cells of the B cell and T cell lineages, but not on most mature resting peripheral lymphocytes. It is also present on thymocytes, pre-B cells, germinal center B cells, mitogen-activated T cells, immunoglobulin-secreting plasma cells, monocytes, NK cells, and erythroid and myeloid progenitors in bone marrow. CD38 acts as a NAD glycohydrolase on T lymphocytes. Monoclonal antibodies against human and mouse CD38 have a wide range of biological effects, including the induction of B and T cell proliferation, protection of B cells from apoptosis, inhibition of B lymphopoiesis and enhancement of macrophage antigen presenting cell function.1-2
Suitable for use in Flow Cytometry, Immunohistochemistry and Western Blot. Other applications have not been tested.
Flow Cytometry: 5ul/10e6 cells
Optimal dilutions to be determined by the researcher.
Storage and Stability:
May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degrees C. Aliquots are stable for at least 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.