CD38 is a 45kD type II single-chain transmembrane glycoprotein. It is found on immature cells of the B cell and T cell lineages, but not on most mature resting peripheral lymphocytes. It is also present on thymocytes, pre-B cells, germinal center B cells, mitogen-activated T cells, immunoglobulin-secreting plasma cells, monocytes, NK cells, and erythroid and myeloid progenitors in bone marrow. CD38 acts as a NAD glycohydrolase on T lymphocytes. Monoclonal antibodies against human and mouse CD38 have a wide range of biological effects, including the induction of B and T cell proliferation, protection of B cells from apoptosis, inhibition of B lymphopoiesis and enhancement of macrophage antigen presenting cell function.1-2
Suitable for use in Flow Cytometry, Immunohistochemistry (frozen sections) and Western Blot. Other applications not tested.
Flow Cytometry: 5ul/10e6 cells
Optimal dilutions to be determined by the researcher.
Storage and Stability:
May be stored at 4 degrees C before opening. DO NOT FREEZE! Stable at 4 degrees C as an undiluted liquid. Dilute only prior to immediate use. Stable for at least 12 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.