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CD34 (Endothelial Cell Marker, Cluster Designation 34, Hematopoietic Progenitor Cell Antigen CD34, HPCA1) (PE/Cy5.5)

Cat no: C2386-28G

Supplier: United States Biological
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CD34 is a 110-120kD heavily O-glycosylated type I transmembrane glycoprotein. It is expressed on a small subpopulation (2-4%) of bone marrow cells including hematopoietic stem cells, small vessel endothelial cells and tumors of epithelial origin, and a subset of fibroblasts. It is believed that hematopoietc CD34 plays a role in modulating adhesion and as well as signal tranduction through its phosphorylation by activated protein kinase C. Applications:
Catalogue number: C2386-28G
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Immunohistochemistry
Size: 100Tests
Form: Supplied as a liquid in phosphate buffered saline, 0.1% sodium azide. Conjugated to PE/Cy5.5.
P type: Mab
Isotype: IgG1
Purity: Purified
References: 1. Schlossman, S., L. Bloumsell, W. Gilks, J.M. Harlan, C. Kishimoto, J. Ritz, S. Shaw, R. Silverstein, T. Springer, T.F. Tedder, and R.F. Todd, eds. 1995. Leukocyte Typing V: White Cell Differentiation Antigens, Oxford University Press, Oxford. 2. Barclay, A.N., M.H. Brown, S.K.A. Law, A.J. McKnight, M.G. Tomlinson, and P.A. van der Merwe, eds. 1997. The Leukocyte Antigens Facts Book, 2nd Edition, CD34 Section, Academic Press, New York, p. 215. 3. Civin, C., L.C. Strauss, C. Brovall, M.J. Fackler, J.F. Schwartz, and J.H. Shaper. 1984. J. Immunol. 133:157. 4. Sutherland, D.R., M.J. Fackler, W.S. May, K. Matthews, and M.A. Baker. 1992. Leuk. Lymphoma 8:337. 5. Watt, S.M., K. Karhi, K. Gatter, A.J. Furley, F.E. Katz, L.E. Healy, L.J. Altass, N.J. Bradley, D.R. Sutherland, R. Levinsky, et al. 1987. Leukemia 1:417. 6. Schlingemann, R.O., F.J. Rietveld, R.M. de Waal, N.J. Bradley, A.I. Skene, A.J. Davies, M.F. Greaves, J. Denekamp, and D.J. Ruiter. 1990. Lab Invest. 62:690. 7. Fina, L., H.V. Molgaard, D. Robertson, N.J. Bradley, P. Monaghan, D. Delia, D.R. Sutherland, M.A. Baker, and M.F. Greaves. 1990. Blood 12:2417. 8. Majdic, O., J. Stockl, W.F. Pickl, J. Bohuslav, H. Strobl, C. Scheinecker, H. Stockinger, and W. Knapp. 1994. Blood 83:1226.
Additional info: Recognizes human CD34 Class III epitope which is resistant to neuraminidase, chymopapain and glycoprotease.

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