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CD34 (Endothelial Cell Marker, Cluster Designation 34, Hematopoietic Progenitor Cell Antigen CD34, HPCA1) (APC)

CD34 (Endothelial Cell Marker, Cluster Designation 34, Hematopoietic Progenitor Cell Antigen CD34, HPCA1) (APC)

Cat no: C2386-28E

Supplier: United States Biological
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CD34 is a 110-120kD heavily O-glycosylated type I transmembrane glycoprotein. It is expressed on a small subpopulation (2-4%) of bone marrow cells including hematopoietic stem cells, small vessel endothelial cells and tumors of epithelial origin, and a subset of fibroblasts. It is believed that hematopoietc CD34 plays a role in modulating adhesion and as well as signal tranduction through its phosphorylation by activated protein kinase C. Applications: Suitable for use in Flow cytometry, Immunohistochemistry (frozen sections). Other applications not tested. Recommended Dilution: Flow Cytometry: 5ul/10e6 cells Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C. For long-term storage, aliquot and store at 4 degrees C. Do not freeze. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer. Note: We do not recommend adding glycerol as a cryopreservative.
Catalogue number: C2386-28E
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Immunohistochemistry
Size: 100Tests
Form: Supplied as a liquid in PBS, 0.1% sodium azide and a stabilizing agent. Conjugated to APC.
P type: Mab
Isotype: IgG1
Purity: Purified
References: 1. Schlossman, S., L. Bloumsell, W. Gilks, J.M. Harlan, C. Kishimoto, J. Ritz, S. Shaw, R. Silverstein, T. Springer, T.F. Tedder, and R.F. Todd, eds. 1995. Leukocyte Typing V: White Cell Differentiation Antigens, Oxford University Press, Oxford. 2. Barclay, A.N., M.H. Brown, S.K.A. Law, A.J. McKnight, M.G. Tomlinson, and P.A. van der Merwe, eds. 1997. The Leukocyte Antigens Facts Book, 2nd Edition, CD34 Section, Academic Press, New York, p. 215. 3. Civin, C., L.C. Strauss, C. Brovall, M.J. Fackler, J.F. Schwartz, and J.H. Shaper. 1984. J. Immunol. 133:157. 4. Sutherland, D.R., M.J. Fackler, W.S. May, K. Matthews, and M.A. Baker. 1992. Leuk. Lymphoma 8:337. 5. Watt, S.M., K. Karhi, K. Gatter, A.J. Furley, F.E. Katz, L.E. Healy, L.J. Altass, N.J. Bradley, D.R. Sutherland, R. Levinsky, et al. 1987. Leukemia 1:417. 6. Schlingemann, R.O., F.J. Rietveld, R.M. de Waal, N.J. Bradley, A.I. Skene, A.J. Davies, M.F. Greaves, J. Denekamp, and D.J. Ruiter. 1990. Lab Invest. 62:690. 7. Fina, L., H.V. Molgaard, D. Robertson, N.J. Bradley, P. Monaghan, D. Delia, D.R. Sutherland, M.A. Baker, and M.F. Greaves. 1990. Blood 12:2417. 8. Majdic, O., J. Stockl, W.F. Pickl, J. Bohuslav, H. Strobl, C. Scheinecker, H. Stockinger, and W. Knapp. 1994. Blood 83:1226.
Additional info: Recognizes human CD34 Class III epitope which is resistant to neuraminidase, chymopapain and glycoprotease.

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