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CD25 (Tac antigen, p55, Interleukin 2 Receptor alpha, IL2Ra, T Cell Growth Factor Receptor) (PE)

Cat no: C2275-83D


Supplier: United States Biological
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Expression of human CD25 (the alpha subunit of the IL-2 receptor complex) is dramatically upregulated on activated T cells, B cells, NK cells and macrophages (3). Antibodies to CD25 are being studied for potential use as an immundirected therapy to selectively attack (kill) CD25 expressing cells (4). Functional
Catalogue number: C2275-83D
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Immunohistochemistry
Size: 120Tests
Form: Supplied as a liquid in PBS, pH 7.2, 15% glycerol, 0.2% BSA, 0.05% sodium azide.
P type: Mab
Isotype: IgG2a
Purity: Purified by Protein A affinity chromatography.
References: (1) L.A. Rubin, et al, (1985) Hybidoma 4: 91-102. (2) B. Boutin, et al, (1989) Neuropediatrics 20: 202-206. (3) T.A. Waldmann, et al, (1989) Annu Rev Biochem 58: 875-911. (4) T.A. Waldmann, et al, (1995) Blood 86: 4063-4075. (5) U.S. Patent No. 4,707,443. (6) Leukocyte Typing IV (W. Knapp, et al, eds.) Oxford University Press, Oxford, (1989) p. 403-406
Additional info: Recognizes epitope B of the IL-2 alpha receptor of about 55kD. Does not block IL-2 binding to its receptor.

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