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CD23 (IgE Receptor gp45) (FITC)

Cat no: C2273-89Y

Supplier: United States Biological
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CD23 is a 45kD type II integral membrane glycoprotein that is the low affinity receptor for IgE. It also binds to CD21, and the alpha chains of CD11b and CD11c. It is expressed by B cells and monocytes and, weakly, on T cells, follicular dendritic cells, eosinophils, NK cells, Langerhans cells and platelets. It is upregulated in response to B cell activation, CD40 ligation, or in response to IL-4 or IL-13. CD23 is responsible for regulation of IgE synthesis and may play a role in antigen presentation by B cells and follicular dendritic cells by interacting with CD40.1-7 Applications:
Catalogue number: C2273-89Y
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Immunohistochemistry, Immunoprecipitation
Size: 100Tests
Form: Supplied as a liquid in PBS, 0.1% sodium azide and a stabilizing agent. Conjugated to FITC.
P type: Mab
Isotype: IgG3
Purity: Purified
References: 1. McMichael, A.K., P.C.L. Beverly, S. Cobbold, M.J. Crumpton, W. Gilks, F.M. Gotch, N. Hogg, M. Horton, N. Ling, I.C.M. MacLennan, D.Y. Mason, C. Milstein, D. Spiegelhalter, and H. Waldmann, eds. 1987. Leukocyte Typing III: White Cell Differentiation Antigens, Oxford University Press, Oxford. 2. Knapp, W., B. Dorken, W.R. GIlks, E.P. Rieber, R.E. Schmidt, H. Stein, A.E.G.K. Von dem Borne, eds. 1989. Leukocyte Typing IV: White Cell Differentiation Antigens, Oxford University Press, Oxford. 3. Barclay, A.N., M.H. Brown, S.K.A. Law, A.J. McKnight, M.G. Tomlinson, and P.A. van der Merwe, eds. 1997. The Leukocyte Antigens Facts Book, 2nd Edition, CD23 Section, Academic Press, New York, p. 189. 4. Gordon, J. 1991. Clin. Exp. Immunol. 86:356. 5. Bonnefoy, J.-Y, S. Lecoanet-Henchoz, J.P. Aubry, J.F. Gauchat, and P. Graber. 1995. Curr. Opin. Immunol. 7:355. 6. Bonnefoy, J.-Y., C. Plater-Zyberk, S. Lecoanet-Henchoz, J.-F. Gauchat, J.-P. Aubry, and P. Graber. 1996. Immunol. Today 17:418. 7. Lamers, M.C., and P. Yu, 1995. Immunol. Rev. 148:71.
Additional info: Recognizes human CD23.

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