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CD146, Recombinant, Human (Mucin 18, MUC18 Glycoprotein, Melanoma Associated Antigen A32, S-endo 1 Endothelial Associated Antigen, Melanoma Adhesion Molecule Mel-CM)

CD146, Recombinant, Human (Mucin 18, MUC18 Glycoprotein, Melanoma Associated Antigen A32, S-endo 1 Endothelial Associated Antigen, Melanoma Adhesion Molecule Mel-CM)

Cat no: C2548-78R

Supplier: United States Biological
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CD146 (aa433-647) belongs to the immunoglobulin supergene family with five immunoglobulin like domains (V-V-C2-C2-C2), a transmembrane region and a 63 residue cytoplasmic tail. The protein is a membrane glycoprotein that functions as a Ca2+ independent cell adhesion molecule involved in heterophilic cell to cell interactions. CD146 has a molecular size of 130kD in its reduced form (118kD unreduced), and N linked glycosylation accounts for fifty percent of the apparent molecular weight. In some cells the molecule carries a sulfate 3 glucuronyl moiety. Applications: Suitable for use in ELISA, Western Blot and Inhibition assays. Other applications not tested. Recommended Dilutions: Optimal dilutions to be detrmined by the researcher. Storage and Stability: For long-term storage, aliquot and stoe at -20 degrees C. Aliquots are stable for at least 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C2548-78R
Size: 2ug
Form: Supplied as a liquid in 50mM Tris-acetate, pH 7.5, 1mM EDTA, 20% glycerol.
Purity: Purified by proprietary chromatographic techniques. On SDS-PAGE commassie blue stained gel, the purified recombinant protein shows a band at 47kD
References: 1. Differential CD146 expression on circulating versus tissue endothelial cells in rectal cancer patients: implications for circulating endothelial and progenitor cells as biomarkers for antiangiogenic therapy. J Clin Oncol 2006 Mar 20;24(9):1449-53. 2. Knockdown of CD146 reduces the migration and proliferation of human endothelial cells. Cell Res 2006 Mar;16(3):313-8. 3. The first assessment of soluble CD146 in women with unexplained pregnancy loss. A new insight Thromb Haemost 2005 Dec;94(6):1280-4. 4. Presence of endothelial progenitor cells, distinct from mature endothelial cells, within human CD146+ blood cells. Thromb Haemost 2005 Dec;94(6):1270-9. 5. Increased expression of CD146, a new marker of the endothelial junction in active inflammatory bowel disease. Inflamm Bowel Dis 2006 Jan;12(1):16-21. 6. CD146 (Mel-CAM), an adhesion marker of endothelial cells, is a novel marker of lymphocyte subset activation in normal periphera l blood. Blood 2005 Oct 15;106(8):2923-4

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