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CD11a (Leukocyte Function Associated Antigen, LFA-1, Integrin aL) (FITC)

Cat no: C2262-02E

Supplier: United States Biological
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Human CD11a (alpha L integrin) complexes with CD18 (beta2 integrin) to form the LFA-1 heterodimer adhesion molecule which binds to three ICAM's 1, 2, and 3, also designated CD54, CD102, and CD50 respectively. LFA-1 is expressed on lymphocytes, monocytes and neutrophils and plays a role in cell-cell adhesion. Functional Application: Antibody blocks binding of ICAM-1 and ICAM-3 to LFA-1 at 5-10ug/ml (7). Applications: Suitable for use in Flow Cytometry and Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, store at -20 degrees C. Aliquots are stable for at least 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C2262-02E
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Western Blot
Size: 120Tests
Form: Supplied as a liquid in PBS, pH 7.2, 5% glycerol, 0.2% BSA, 0.05% sodium azide.
P type: Mab
Isotype: IgG2a
Purity: Purified by Protein A affinity chromatography.
References: 1. I. Dransfield & N. Hogg, (1989) EMBO J 12: 3759-3765. 2. Leukocyte Typing V (S.F. Schlossman,et al, eds.) Oxford University Press, Oxford, (1995) p. 1581-1592. 3. R.C. Landis, et al, (1994) J Cell Biol 126: 529-537. C.L. Holness, et al, (1995) J Biol Chem 270: 877-884.
Additional info: Recognizes the I domain of the integrin alpha L subunit (CD11a) of about 180kD.

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