Home  >  Products  >  CD106 (Vascular Cell Adhesion Molecule-1, VCAM-1, INCAM-110) (FITC)
CD106 (Vascular Cell Adhesion Molecule-1, VCAM-1, INCAM-110) (FITC)

CD106 (Vascular Cell Adhesion Molecule-1, VCAM-1, INCAM-110) (FITC)

Cat no: C2446-71C

Supplier: United States Biological
Star_fadedStar_fadedStar_fadedStar_fadedStar_faded
0 reviews | Write a Review Pencil
Read More on Supplier Website
CD106, also known as INCAM-1, is a 100-110kD vascular adhesion cell adhesion molecule-1 (VCAM-1) that is member of the immunoglobulin superfamily. CD106 is expressed predominantly on cytokine-activated vascular endothelium but has also been identified on interfollicular dendritic cells, some macrophages and bone marrow stromal cells. Endothelial CD106 binds the integrins alpha4beta1 (CD49d/CD29, VLA-4) and alpha4beta7 and contributes to extravasation of lymphocytes, monocytes, basophils and eosinophils (but not neutrophils) from blood vessels, particularly at sites of inflammation. Unlike the beta2 integrins, the CD106-VLA-4 interaction can mediate both the initial tethering and rolling of lymphocytes on endothelium as well as their subsequent arrest and firm adhesion. CD106 expressed on non-vascular tissues has been implicated in the interaction of hematopoietic progenitors with bone marrow stromal cells, B cell binding to follicular dendritic cells, costimulation of T cells, and embryonic development (1-4). Applications: Suitable for use in Flow Cytometry, ELISA, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Flow Cytometry: 10ul/1x10e6 cells Immunohistochemistry: Frozen Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. FITC conjugates are sensitive to light.
Catalogue number: C2446-71C
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Flow Cytometry, Immunohistochemistry, Western Blot
Size: 100Tests
Form: Supplied as a liquid in PBS, 0.1% sodium azide. Labeled with FITC.
P type: Mab
Isotype: IgG1
Purity: Purified
References: 1. Schlossman, S., et al. 1995. Leukocyte Typing V: White Cell Differentiation Antigens, Oxford University Press, Oxford. 2. Barclay, A.N., et al. 1997. The Leukocyte Antigens Facts Book, 2nd Edition, CD106 Section, Academic Press, New York, p. 386.3. Thornhill, M.H., et al. 1991. J. Immunol. 146:592.4. Bevilacqua, M.P. 1993. Annu. Rev. Immunol. 11:767.
Additional info: Recognizes human CD106/VCAM-1. Inhibits in vitro binding of lymphocytes and monocytes to VCAM-1 on stimulated endothelium.

Get Quote

  • Best Price Guaranteed
  • Quick Response Time
  • Exclusive Promotions
Enquiry_down_arrow
United States Biological
Get a Quote Direct from
United States Biological

By submitting this form you agree to your details being passed to United States Biological for the purpose of generating the best quote*
See Full Product Listings >
Button_on Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave