Beta-catenin-like protein 1 (CTNNBL1) is an apoptosis inducing protein with a structural homology to beta- catenin and other armadillo family proteins. CTNNBL1 is highly conservered across various species and it is primarily expressed in the nucleus of various tissues (1). In human, CTNNBL1 shows highest expression in skeletal muscle, placenta, heart, spleen, testis, and thyroid tissues. In CHO cells, transient expression of CTNNBL1 cause it to localized
to nucleus and induce apoptosis, with apoptosis inducing activity specific to its carboxy-terminal region (1). CTNNBL1 has been linked to possible role in Wnt/beta-catenin-signaling
pathway and might have similar function as a beta catenin. CTNNBL1 may play an important role in the development of human obesity (2).
Applications:
Suitable for use in Flow Cytometry, Western Blot, Immunoprecipitation, Immunohistochemistry and Immunocytochemistry. Other applications not tested.
Recommended Dilution:
Flow Cytometry: 1:20
Western Blot: 1:2000-1:5000
Immunoprecipitation: 1:40
Immunohistochemistry: 1:100-1:250
Immunocytochemistry: 1:100-1:250
Optimal dilutions to be determined by the researcher.
Storage and Stability:
May be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Manufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.