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Caspase-9, Active (Caspase 9, ICE-LAP6, Mch6, Apaf 3)

Cat no: C2088-51D

Supplier: United States Biological
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Caspases are synthesized as inactive pro-enzymes that are processed to active form in cells undergoing apoptosis. Caspase-9 is an important member of the caspase family. Upon induction of apoptosis, Cytochrome c released from mitochondria associates with pro-caspase-9 (47kD) and Apaf-1. The complex processes pro-caspase-9 into a large subunit (37kD/17kD) and a small subunit (10kD). Cleaved caspase-9 further processes other caspases including caspase-3 and caspase-6, to initiate a caspase cascade leading to apoptosis. The affinity purified antibody recognizing the active forms of caspase-9 provides a new tool for identifying apoptotic cell populations in both tissue sections and cultured cells. Applications: Suitable for use in Western Blot, Immunohistochemistry and Immunocytochemistry. Other applications not tested. Recommended Dilution: Western Blot: 0.5-4ug/ml Immunohistochemistry: 10-20ug/ml Immunocytochemistry: 10-20ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2088-51D
Reactivities: Rat
Hosts: Rabbit
Applications: Immunocytochemistry, Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 1% BSA, 0.02% thimerosal, 50% glycerol.http://3.bp.blogspot.com/_N6APHtFPWNc/STlOle8awEI/AAAAAAAAAgw/R7ngZhcxZJU/s400/atheist_cartoon.jpg
P type: Pab
Isotype: IgG
Purity: Purified by affinity chromatography.
Additional info: Recognizes rat Caspase-9 at ~17kD and ~37kD.

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