Home  >  Products  >  Caspase-9, Active (CASP-9, Apoptotic Protease Mch-6, Apoptotic Protease-activating Factor 3, APAF-3, ICE-like Apoptotic Protease 6, ICE-LAP6, MCH6)

Caspase-9, Active (CASP-9, Apoptotic Protease Mch-6, Apoptotic Protease-activating Factor 3, APAF-3, ICE-like Apoptotic Protease 6, ICE-LAP6, MCH6)

Cat no: C2088-51C


Supplier: United States Biological
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Caspases are synthesized as inactive pro-enzymes that are processed to active form in cells undergoing apoptosis. Caspase-9 is an important member of the caspase family. Upon induction of apoptosis, Cytochrome c released from mitochondria associates with pro-caspase-9 (47kD) and Apaf-1. The complex processes pro-caspase-9 into a large subunit (37kD/17kD) and a small subunit (10kD). Cleaved caspase-9 further processes other caspases including caspase-3 and caspase-6, to initiate a caspase cascade leading to apoptosis. The affinity purified antibody recognizing the active forms of caspase-9 provides a new tool for identifying apoptotic cell populations in both tissue sections and cultured cells. Applications: Suitable for use in Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilution: Western Blot: 0.5-4ug/ml Immunoprecipitation: 10-20ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2088-51C
Reactivities: Human
Hosts: Rabbit
Applications: Immunoprecipitation, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.5% BSA, 0.02% thimerosal, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Affinty purified
Additional info: Recognizes human Caspase-9 at ~37kD.

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