Home  >  Products  >  c-Cbl, phosphorylated (Tyr700) (C CBL, Cas-Br-M (murine) ecotropic retroviral transforming sequence, Casitas B lineage lymphoma proto oncogene, CBL 2, CBL2, E3 ubiquitin protein ligase CBL, Oncogene CBL2, Proto oncogene c CBL, RING finger protein 55, RNF5
c-Cbl, phosphorylated (Tyr700) (C CBL, Cas-Br-M (murine) ecotropic retroviral transforming sequence, Casitas B lineage lymphoma proto oncogene, CBL 2, CBL2, E3 ubiquitin protein ligase CBL, Oncogene CBL2, Proto oncogene c CBL, RING finger protein 55, RNF5

c-Cbl, phosphorylated (Tyr700) (C CBL, Cas-Br-M (murine) ecotropic retroviral transforming sequence, Casitas B lineage lymphoma proto oncogene, CBL 2, CBL2, E3 ubiquitin protein ligase CBL, Oncogene CBL2, Proto oncogene c CBL, RING finger protein 55, RNF5

Cat no: C0013-25D

Supplier: United States Biological
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c-Cbl, product of c-cbl proto-oncogene, is a 120kDa cytoplasmic protein involved in tyrosine kinase-dependent signaling pathways (1-3). c-Cbl is one of the earliest targets of tyrosine phosphorylation in response to a number of cellular stimuli. For instance, stimulation of growth factor receptors by EGF, PDGF, NGF and FGF, results in c-Cbl tyrosine phosphorylation, in lymphoid and other cell lines (4). It has been demonstrated that tyrosines 700, 731, and 774 are the major tyrosine phosphorylation sites of c-Cbl in T cells in response to pervanadate treatment, as well as in response to TcR/CD3 ligation (5). Applications: Suitable for use inFlow Cytometry, Western Blot, Immunoprecipitation. Other applications not tested. Recommended Dilution: Western Blot: 1:5000-1:10,000 Flow Cytometry: 1:50 Immunoprecipitation: 1:40 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Manufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Catalogue number: C0013-25D
Reactivities: Human
Hosts: Rabbit
Applications: Flow Cytometry, Immunoprecipitation, Western Blot
Size: 100ul
Form: Supplied as a liquid in 50mM Tris-glycine, pH 7.4, 0.15M sodium chloride, 40% glycerol, 0.01% sodium azide, 0.05% BSA.
P type: Mab
Isotype: IgG
Purity: Supernatant
References: 1. Langdon, W. Y., et al. Proc. Natl. Acad. Sci. USA 86: 1168
Additional info: Recognizes human Cbl phosphorylated on tyrosine 700.

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