Home  >  Products  >  Bim (Apoptosis Facilitator, BAM, Bcl2 Interacting Mediator of Cell Death, Bcl-2-interacting Mediator of Cell Death, Bcl 2 Interacting Protein Bim, Bcl-2-interacting Protein Bim, Bcl 2 Like Protein 11, Bcl2-like Protein 11, Bcl 2 Related Ovarian Death Agon

Bim (Apoptosis Facilitator, BAM, Bcl2 Interacting Mediator of Cell Death, Bcl-2-interacting Mediator of Cell Death, Bcl 2 Interacting Protein Bim, Bcl-2-interacting Protein Bim, Bcl 2 Like Protein 11, Bcl2-like Protein 11, Bcl 2 Related Ovarian Death Agon

Cat no: B1090-02A


Supplier: United States Biological
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Apoptosis or programmed cell death is a physiological cellular process characterized by cell shrinkage, membrane blebbing, DNA fragmentation, and release of Cytochrome C from the mitochondria. It is utilized by the organism to get rid of unwanted cells, which is critical for normal development and homeostasis of an organism. Disregulation of normal apoptosis process have been implicated in a variety of diseases, including cancer, autoimmune diseases, viral infections, etc. Programmed cell death occurs through complex cascades of cell signaling in which Bcl-2 family members, among others, play an important role.The Bcl-2 family of proteins regulate apoptosis as well as execute death signals at the mitochondrion. Members of this family include both pro- and anti-apoptotic proteins that hare homology sequences called Bcl-2 Homology domains (BH1-4) which mediate dimer formation. The BH3 proteins, such as BID, NOXA, PUMA, BIK, BIM and BAD are all pro-apoptotic and share sequence homology within the amphipathic alpha-helical BH3 region, which is required for their apoptotic function. They may trigger release of death-inducing molecules such as Cytochrome C, Smac, and endonuclease G. Anti-apoptotic family members, including Bcl-2 and Bcl-XL, play inhibitory roles. Bcl-2 family proteins may form homodimers or heterodimers between pro- and anti-apoptotic members, the ratios of which determine the cell fate. Applications: Suitable for use in ELISA, Western Blot, Immunohistochemistry and Immunoprecipitation. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: B1090-02A
Reactivities: Human, Mouse
Hosts: Mouse
Applications: ELISA, Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.02% sodium azide.
P type: Mab
Isotype: IgG
Purity: Purified
Additional info: Recognizes human Bim. Species crossreactivity: mouse.

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