Home  >  Products  >  BID (Bcl-2 Interacting Domain, BH3 Interacting Domain Death Agonist, BH3-interacting Domain Death Agonist p11, BH3-interacting Domain Death Agonist p13, BH3-interacting Domain Death Agonist p15, BID Isoform ES(1b), BID Isoform L(2), Apoptotic Death Agonis

BID (Bcl-2 Interacting Domain, BH3 Interacting Domain Death Agonist, BH3-interacting Domain Death Agonist p11, BH3-interacting Domain Death Agonist p13, BH3-interacting Domain Death Agonist p15, BID Isoform ES(1b), BID Isoform L(2), Apoptotic Death Agonis

Cat no: B1095-01T


Supplier: United States Biological
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Apoptosis or programmed cell death is a physiological cellular process characterized by cell shrinkage, membrane blebbing, DNA fragmentation, and release of Cytochrome C from the mitochondria. It is utilized by the organism to get rid of unwanted cells, which is critical for normal development and homeostasis of an organism. Disregulation of normal apoptosis process have been implicated in a variety of diseases, including cancer, autoimmune diseases, viral infections, etc. Programmed cell death occurs through complex cascades of cell signaling in which Bcl-2 family members, among others, play an important role.The Bcl-2 family of proteins regulate apoptosis as well as execute death signals at the mitochondrion. Members of this family include both pro- and anti-apoptotic proteins that hare homology sequences called Bcl-2 Homology domains (BH1-4) which mediate dimer formation. The BH3 proteins, such as BID, NOXA, PUMA, BIK, BIM and BAD are all pro-apoptotic and share sequence homology within the amphipathic alpha-helical BH3 region, which is required for their apoptotic function. They may trigger release of death-inducing molecules such as Cytochrome C, Smac, and endonuclease G. Anti-apoptotic family members, including Bcl-2 and Bcl-XL, play inhibitory roles. Bcl-2 family proteins may form homodimers or heterodimers between pro- and anti-apoptotic members, the ratios of which determine the cell fate. Applications: Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunoprecipitation, Flow Cytometry / FACS analysis Other applications have not been tested Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degrees C. Aliquots are stable for at least 3 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: B1095-01T
Reactivities: Human, Mouse
Hosts: Mouse
Applications: ELISA, Flow Cytometry, Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.02% sodium azide.
P type: Mab
Isotype: IgG
Purity: Purified by ammonium sulfate precipitation.
Additional info: Recognizes human and mouse Bid.

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